Microencapsulation of Diclofenac Sodium by Non-solvent
M Ahmad1* and G Shahnaz2
of Pharmacy, Faculty of Pharmacy and Alternative
Medicines, The Islamia University of Bahawalpur,
Bahawalpur 63100, Pakistan, 2Department of
Pharmaceutical Sciences, Faculty of Pharmacy,
University of Innsbruck, Austria.
firstname.lastname@example.org Tel: +92-300-9682258
(mobile), 62-9255243; Fax: +92-62-9255565
Received: 26 July 2009
Revised accepted: 21
Journal of Pharmaceutical Research, April 2010;
Purpose: To prepare, using non-solvent addition technique,
diclofenac sodium-ethylcellulose microparticles with
modified drug release properties.
Methods: Microparticles were prepared by non-solvent addition phase
separation method and characterized by micromeritics,
scanning electron microscopy (SEM), Fourier transform
infrared spectroscopy (FTIR), x-ray diffraction (XRD),
dissolution test and thermal analysis.
Results: The microparticles were whitish, irregular, aggregated,
and in the size range of 390 - 442 Ám size. Drug
embedment efficiency was 89 - 91 %. Characterisation
studies indicate that there was no strong chemical
interaction between the drug and the polymer in the
microparticles. Polymer concentration and sustained
release behavior were directly proportional.
Conclusion: Non-solvent addition phase separation is a suitable method
for preparing diclofenac sodium-ethylcellulose
multi-unit controlled release drug delivery system.
Phase separation, Diclofenac sodium, Ethylcellulose,
Non-solvent addition, Characterisation.