Ning Xia1,
Bao-an Li2,
Hai-ju Liu3,
Jiu-bo Fan4,
Wei Shen1,
Xiu-guo He5 
For correspondence:- Xiu-guo He Email: hexiuguo133494@sina.com Tel:+867103528933
Received: 31 March 2016 Accepted: 8 May 2017 Published: 29 June 2017
Citation: Xia N, Li B, Liu H, Fan J, Shen W, He X. Anti-hyperuricemic effect of Plantago depressa Willd extract in rats. Trop J Pharm Res 2017; 16(6):1365-1368 doi: 10.4314/tjpr.v16i6.21
© 2017 The authors.
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Purpose: To investigate the effects of Plantago depressa Willd. extract (PDWE) on hyperuricemia in rats.
Methods: The effect of PDWE was investigated in hyperuricemic rats induced by potassium oxonate. PDWE were fed to hyperuricemic rats daily at a dose of 160, 320 and 640 mg/kg for 10 days; allopurinol (5 mg/kg) was given as positive control. Serum and urine levels of uric acid and creatinine were determined by colorimetric method.
Results: PDWE inhibited xanthine oxidase (XOD) activity in serum (16.36 ± 1.16 U/L, p < 0.05) and liver (72.15 ± 5.26 U/g protein, p < 0.05), and also decreased levels of serum uric acid (2.43 ± 0.59 mg/L, p < 0.05), serum creatinine (0.42 ± 0.15 µmol/L) and blood urea nitrogen (BUN, 9.58 ± 0.72 mmol/L, p < 0.05), but increased levels of urine uric acid (39.23 ± 8.22 mg/L, p < 0.05) and urine creatinine (32.24 ± 1.69 mmol/L, p < 0.05) in the renal tissue of hyperuricemic rats.
Conclusion: PDWE exerts uricosuric action by regulating renal urate transporters to ameliorate renal dysfunction in hyperuricemic rats.
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