Xiao Ning Zhao1,3,
Xiu Fen Wang2,
Jin Bin Liao2,
Hui Zhen Guo2,
Xiao Dan Yu2,
Jia Li Liang2,
Xie Zhang2,
Zi Ren Su2,
Xiao Jun Zhang2 
,
Hui Fang Zeng1
For correspondence:- Xiao Zhang Email: zhangxj@gzucm.edu.cn, gancaozhf@126.com Tel:+862039358517
Received: 20 December 2014 Accepted: 22 February 2014 Published: 31 March 2015
Citation: Zhao XN, Wang XF, Liao JB, Guo HZ, Yu XD, Liang JL, et al. Antifatigue effect of Millettiae speciosae Champ (Leguminosae) extract in mice. Trop J Pharm Res 2015; 14(3):479-485 doi: 10.4314/tjpr.v14i3.17
© 2015 The authors.
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Purpose:To evaluate whether Millettiae Speciosae Champ. (Leguminosae) can enhance exercise performance as well as ascertain if it a potential functional food material.
Methods:The extract of Millettia speciosa Champ. (MSE) was orally administered to mice in 500, 1000, 2000 mg/kg doses to investigate its anti-fatigue effect in both forced swimming and climbing tests. Glycogen, triglyceride (TG), blood urea nitrogen (BUN) and creatine phosphokinase (CK) levels in plasma which can indicate alterations in energy utilization during exercise performance, were determined to analyze the operating exercise mechanisms.
Results:The results showed that swimming time to exhaustion was longer in all treated groups (41.06 ± 1.92, 47.84 ± 1.60, 54.00 ± 2.45 min for 500, 10000 and 2000 mg/kg doses, respectively) than for control (19.45 ± 0.62 min, p < 0.05). The middle and high doses of MSE-treated groups significantly prolonged the climbing time compared with control (p < 0.05). Furthermore, MSE reduced the content of TG significantly by increasing fat utilization, delayed the accumulation of BUN and decreased the level of CK (p < 0.05). In addition, administration of MSE significantly protected the depletion of muscle glycogen when compared with control (p < 0.05).
Conclusion:The results show for the first time that Millettia speciosa Champ. (Leguminosae) has significant anti-fatigue activity, and also suggest that it is a potential functional food material.
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