Zainab Ismail Abdul Ameer Al-Mosawi¹, Reyadh H Al-Mosawi¹, Mufeed Jalil Ewadh²

¹Department of Pharmacology and Toxicology, College of Medicine,; ²Department of Biochemistry, College of Medicine, University of Babylon, Iraq.

For correspondence:-  Zainab Ismail Al-Mosawi   Email:

Received: 12 May 2026        Accepted: 22 July 2026        Published: 31 July 2026

Citation: Al-Mosawi ZA, Al-Mosawi RH, Ewadh MJ. Effect of carbamazepine in pentylenetetrazole-induced epilepsy in rat model. Trop J Pharm Res 2026; 25(7):941-946 doi: https://dx.doi.org/10.4314/tjpr.v25i7.5

© 2026 The authors.
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Abstract

Purpose: To investigate the effects of carbamazepine on oxidative stress biomarkers and seizure associated behavioral alterations in pentylenetetrazole (PTZ)-induced epilepsies. Method: A total of 15 adult male Wistar rats were randomly assigned into three groups (n = 5 in each group). Group 1 was the control group and received 0.9 % normal saline, group 2 received PTZ (40 mg/kg intraperitoneal), and group 3 received carbamazepine (CBZ; 50 mg/kg, oral gavage) 1 hour before PTZ administration for 14 days. Seizure latency, frequency, and duration were assessed. Oxidative stress biomarkers, including superoxide dismutase (SOD), glutathione (GSH), and malondialdehyde (MDA), were determined in brain homogenates using standard spectrophotometric methods. Results: Pentylenetetrazole-induced changes in all measured parameters were significant at p < 0.001. However, following carbamazepine treatment, the increases in SOD and GSH were significant at p < 0.05, whereas the improvements in seizure latency, seizure frequency, seizure duration, and MDA were significant at p < 0.001. Conclusion: The study reveals that modulating oxidative stress may play a potential role in mediating the neuroprotective effects of CBZ, suggesting a promising therapeutic target in epileptogenesis.

Keywords: Carbamazepine, Epileptogenesis, Oxidative stress biomarkers, Pentylenetetrazole-induced kindling, Seizure behavior

Impact Factor
Thompson Reuters (ISI): 0.6 (2023)
H-5 index (Google Scholar): 49 (2023)