Haidong Liang1,2,
Fang Fu3,
Bo Yuan2,
Zheng Nan Zhao2,
Chang Gui Tong2,
Xue Hui Liu2,
ShuFang Wu1 
For correspondence:- ShuFang Wu Email: sfangwu@aliyun.com Tel:+862985324555
Accepted: 14 October 2017 Published: 31 January 2018
Citation: Liang H, Fu F, Yuan B, Zhao ZN, Tong CG, Liu XH, et al. Effect of dietary soy isoflavones on bone loss in ovariectomized rats. Trop J Pharm Res 2018; 17(1):91-96 doi: 10.4314/tjpr.v17i1.14
© 2018 The authors.
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Purpose: To determine the effect of dietary soy isoflavone supplementation on bone loss in ovariectomized (OVX) rats.
Methods: Forty-eight rats were assigned randomly to groups of OVX rats receiving soy isoflavones (20, 30, or 40 mg/kg of body weight daily), untreated OVX rats, or untreated intact rats. After 8 weeks, bone mineral density (BMD), mineral (Ca, P, Mn, Mg, and Zn) concentrations, and the ex
Results: Eight weeks after OVX, there was a significant decrease in body weight, serum levels of osteocalcin, alkaline phosphatase, and oestradiol, BMD and mineral elements, as well as the ex
Conclusion: Soy isoflavone treatment represents a potential therapy for preventing postmenopausal bone loss by stimulating the Notch signalling
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