Ibrahim Jafri1 
,
Ghadi Alsharif2,3,
Mohamed El-Sharnouby1,
Basem H Elesawy4,
Osama M Mehanna5,6,
Ahmed ME El-Sharnouby7,
Ahmad EI Askary8
For correspondence:- Ibrahim Jafri Email: dr587@yahoo.com
Received: 2 June 2025 Accepted: 15 May 2026 Published: 31 May 2026
Citation: Jafri I, Alsharif G, El-Sharnouby M, Elesawy BH, Mehanna OM, El-Sharnouby AM, et al. Genetic study of the -243A>G GAD2 promoter polymorphism and its correlation with obesity. Trop J Pharm Res 2026; 25(5):637-642 doi: https://dx.doi.org/10.4314/tjpr.v25i5.5
© 2026 The authors.
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Purpose: To investigate the link between obesity and the -243A>G polymorphism in the glutamate decarboxylase 2 GAD2 gene. Method: This study involved 20 obese participants (which constituted the study group) from Al Azhar University Hospital, recruited between January 2024 and January 2025, and a control group of 20 healthy participants. -243A>G GAD2 polymorphism was identified in the peripheral blood of both study and control groups using polymerase chain reaction-restriction fragment length polymorphism (PCR RFLP) technique. Result: This study found that control group had significantly higher frequencies of the AA genotype and “A” allele compared to study group (p < 0.01). Furthermore, frequencies of the AG and GG genotypes, in addition to the “G” allele, were significantly higher in study group compared to control group (p < 0.01). Conclusion: The study revealed a significant link between the -243A>G polymorphism and obesity.
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