Sheryar Afzal1 
,
Yuan Seng Wu2,
Chan Zelynn1,
V Appalaraju2
For correspondence:- Sheryar Afzal Email: safzal@kfu.edu.sa Tel:+966563840308
Accepted: 27 February 2024 Published: 31 March 2024
Citation: Afzal S, Wu YS, Zelynn C, Appalaraju V. In vitro cytotoxic activity of Sansevieria trifasciata against various cancer cell lines. Trop J Pharm Res 2024; 23(3):491-499 doi: 10.4314/tjpr.v23i3.2
© 2024 The authors.
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Purpose: To determine the in vitro anticancer properties of Sansevieria trifasciata extracts.
Methods: The cytotoxic activity of n-hexane, ethyl acetate and methanol leaf extracts at different concentrations was assessed against Vero, pancreatic (AsPC-1), lung (A549), esophageal squamous carcinoma (KYSE 150) and rhabdomyosarcoma (RD) cancer cell lines using MTT assay. The apoptosis-inducing potential of selected S. trifasciata leaf extract was determined using a caspase 3/7 assay kit.
Results: Ethyl acetate extract of S. trifasciata leaf showed significant anticancer activity against RD cells and methanol extract against KYSE cells (p < 0.05). Ethyl acetate and methanol extract possessed higher toxicity towards RD and KYSE 150 cell lines and exhibited relatively lower toxicity towards Vero normal cells. Ethyl acetate extract-treated RD cells and KYSE 150 cancer cells had more typical apoptotic morphologic features when compared to normal cells.
Conclusion: Sansevieria trifasciata possesses anticancer activity and provides new insights for future molecular work on investigating its utilization in cancer treatment.
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