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Review Article | OPEN ACCESS

Lysicamine in medicinal plants: Biosynthesis and pharmacological activities

Syahira Wahab1, Juriyati Jalil1 , Halimatul Saadiah Mohammad Noor2

1Center for Drug and Herbal Development, Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur; 2School of Pharmacy, Management and Science University, University Drive, Off Persiaran Olahraga, Section 13, 40100 Shah Alam, Selangor, Malaysia.

For correspondence:-  Juriyati Jalil   Email: juriyatijalil@ukm.edu.my

Received: 15 February 2025        Accepted: 22 July 2025        Published: 31 August 2025

Citation: Wahab S, Jalil J, Noor HS. Lysicamine in medicinal plants: Biosynthesis and pharmacological activities. Trop J Pharm Res 2025; 24(8):1069-1080 doi: https://dx.doi.org/10.4314/tjpr.v24i8.12

© 2025 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..

Abstract

Numerous studies have highlighted the significant pharmacological activities of lysicamine in combating and ameliorating various diseases. Nevertheless, a comprehensive compilation of the pharmacological properties of lysicamine has not yet been undertaken. Therefore, this review aimed to provide an extensive overview of the pharmacological applications of lysicamine derived from medicinal plants. Data were collected using several databases, including PubMed, Scopus, and Google Scholar. The findings indicated that lysicamine exhibited diverse pharmacological activities, including anti-inflammatory, antimicrobial, antiprotozoal, anticancer, antihypertensive, and other notable effects. This study underscored the potential of lysicamine as a promising lead compound for drug discovery and development, emphasizing its therapeutic significance and the need for further exploration.

Keywords: Lysicamine, Oxoaporphine alkaloids, Medicinal plants, Pharmacological activities, Biosynthesis

Impact Factor
Thompson Reuters (ISI): 0.6 (2023)
H-5 index (Google Scholar): 49 (2023)

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