Cen Su1,
Ping Niu2 
,
Yao-ming Xu3,
Ye Feng2,
Hai-ping Xia1
For correspondence:- Ping Niu Email: niuping494@126.com Tel:+8651184425614
Accepted: 23 August 2019 Published: 01 October 2019
Citation: Su C, Niu P, Xu Y, Feng Y, Xia H. Protective effect of Acorus tatarinowii extract against alzheimer in 3xTg-AD mice. Trop J Pharm Res 2019; 18(9):1903-1907 doi: 10.4314/tjpr.v18i9.17
© 2019 The authors.
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Purpose: To investigate the protective effect of Acorus tatarinowii extract (ATE) against Alzheimer's disease in 3xTg-AD mice.
Method: The cognitive function of 3xTg-AD mice was assessed using Morris water maze test. The levels of the amyloid beta deposits and NeuN in the hippocampus were evaluated by immunohistochemical assay while brain neurotrophic derived factor (BDNF) and tyrosine kinase B (TrkB) ex
Results: ATE treatment significantly ameliorated learning and memory deficits in AD mice, as shown by increased time spent in the target zone during probe tests. The escape latency in animals treated with 600 mg/kg ATE (24.8 ± 1.3 s) was significantly increased relative to ontreated 3xTg-AD mice (8.5 ± 1.0 s, p < 0.01). In addition, ATE significantly decreased Aβ deposits, increased NeuN-positive cells, and upregulated the ex
Conclusion: These results suggest that ATE treatment may be a useful strategy for managing memory impairment induced by several neurodegenerative diseases.
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