Tropical Journal of Pharmaceutical Research

Original Research Article | OPEN ACCESS

Effect of the intraoperative infusion of recombinant activated coagulation factor VII on short-term prognosis and thoracic complications after acute aortic coarctation

Yilihamujiang Keyoumu¹, Pazelaiti Mohemaiti², Mingming Zhang¹, Qiang Huo¹, Xiang Ma³

¹Department of Cardiovascular Surgery, First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, China; ²Second Department of Comprehensive Internal Medicine, Health Care Center, First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, China; ³Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, China.

For correspondence:- Xiang Ma Email: maxiang_xj@163.com

Accepted: :26 March 2024 Published: 30 April 2024

Citation: Keyoumu Y, Mohemaiti P, Zhang M, Huo Q, Ma X. Effect of the intraoperative infusion of recombinant activated coagulation factor VII on short-term prognosis and thoracic complications after acute aortic coarctation. Trop J Pharm Res 2024; 23(4):731-736 doi: 10.4314/tjpr.v23i4.8

© 2024 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..

Abstract

Purpose: To investigate the impact of intraoperative infusion of recombinant human-activated coagulation factor VII (rFVIIa) on postoperative outcomes in patients with acute aortic dissection (AAD).

Methods: This study involved 120 individuals who underwent aortic coarctation surgery between January 1, 2020, and December 31, 2022 in the First Affiliated Hospital of Xinjiang Medical University, Xinjiang, China. The participants were divided into control (receiving only conventional treatment) and study (receiving rFVIIa infusion in addition to conventional treatment) groups. Various parameters, including patient status, postoperative measures, and complications were evaluated.

Results: There was no significant difference in age, gender distribution, duration of myocardial block, onset time, or surgery duration (p > 0.05) between both groups. However, the study group exhibited longer extracorporeal circulation duration (p < 0.05). The study group also demonstrated lower levels of chest drainage compared to the control group 12 and 24 h after surgery (p < 0.05). Moreover, fewer concentrated red blood cells and fresh frozen plasma transfusions were administered to study group (p < 0.05). Despite having longer stays in the ICU (p < 0.05), the study group required less postoperative mechanical ventilation (p < 0.05). There was a significant difference in the incidence of postoperative thrombosis cases, positive gram-negative bacilli sputum culture results, and deaths within the study group (p < 0.05).

Conclusion: Intraoperative rFVII? infusion in AAD patients enhances short-term prognosis, with elevated risk of chest complications. However, further studies with larger sample sizes is essential to comprehensively assess clinical advantages and drawbacks.

Keywords: Recombinant activated coagulation factor VII, Acute aortic coarctation, Prognosis, Lung infection, Mechanical ventilation, Thrombosis