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Original Research Article | OPEN ACCESS

Molecular characteristics of the protective effect of Bacillus Calmette-Guerin against neonatal sepsis

Chen Kou1,2, Adong Shen1

1Beijing Key Laboratory of Pediatric Respiratory Infection Diseases, Key Laboratory of Major Diseases in Children, Ministry of Education, National Clinical Research Center for Respiratory Diseases, National Key Discipline of Pediatrics (Capital Medical University), Beijing Pediatric Research Institute, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, China; 2Department of Neonatal Intensive Care Unit, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital, Beijing, China.

For correspondence:-  Adong Shen   Email: shenad18@126.com

Accepted: 21 March 2024        Published: 30 April 2024

Citation: Kou C, Shen A. Molecular characteristics of the protective effect of Bacillus Calmette-Guerin against neonatal sepsis. Trop J Pharm Res 2024; 23(4):697-705 doi: 10.4314/tjpr.v23i4.4

© 2024 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..

Abstract

Purpose: To investigate the molecular characteristics and potential mechanisms underlying the immune-protective effect of Bacillus Calmette-Guerin (BCG) against neonatal sepsis (NS).

Methods: Data on transcriptome sequencing of BCG infection, NS, post-BCG infection sepsis, and the respective controls were retrieved from public databases. Systems biology screening was used to identify differentially expressed genes (DEGs) amongst the groups, and common DEGs with high connectivity were selected using protein-protein interaction network analysis.

Results: A total of 15 common DEGs were related to the expressions of macrophages and neutrophils after BCG infection and NS infection. Some of the genes were involved in IL-4/IL-13 signal pathway and neutrophil degranulation pathway, and they were highly correlated with the expressions of TNF-alpha, IL-6 and type I interferon-response signal pathway. This may reduce the poor prognosis of NS after BCG infection.

Conclusion: These findings provide insights into how BCG-induced trained immunity may provide protection against NS.

Keywords: Bacillus Calmette-Guerin (BCG), Neonatal sepsis, Trained Immunity, Differentially expressed genes (DEGs), Transcriptome sequencing data

Impact Factor
Thompson Reuters (ISI): 0.523 (2021)
H-5 index (Google Scholar): 39 (2021)

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