Ahmed Fawzy1,2 
,
Metwally Abdallah1,3,
Nada Alqarni1,4
For correspondence:- Ahmed Fawzy Email: afsaad13@yahoo.com Tel:+966590994316
Accepted: 17 August 2020 Published: 30 September 2020
Citation: Fawzy A, Abdallah M, Alqarni N. Oxidative degradation of some antibiotics by permanganate ion in alkaline medium: A kinetic and mechanistic approach. Trop J Pharm Res 2020; 19(9):1999-2007 doi: 10.4314/tjpr.v19i9.28
© 2020 The authors.
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Purpose: To investigate the kinetics of oxidative removal of two β-lactam antibiotics (A), namely, ampicillin and flucloxacillin.
Methods: In this study, permanganate ion (MnO4-) was used as an oxidant in an alkaline medium at fixed ionic strength of 0.1 mol dm-3 and a temperature of 298 K utilizing a spectrophotometric technique. The obtained oxidation products were characterized using spot tests and FT-IR spectra.
Results: The stoichiometry of the reactions was 1:4 (A : MnO4-). The reactions were a first order credence in [MnO4-] and fractional-first order kinetics in antibiotic and hydroxyl ion. Influence of ionic strength was successfully explored. Dependence of reaction rates on temperature was studied and the activation parameters were computed and discussed. A plausible mechanism for the oxidation reactions has been elucidated. A consistent rate-law ex
Conclusion: This study introduces a significant treatment method for antibiotic removal, thus helping to protect the environment and human health.
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