Open Access


Read more
image01

Online Manuscript Submission


Read more
image01

Submitted Manuscript Trail


Read more
image01

Online Payment


Read more
image01

Online Subscription


Read more
image01

Email Alert



Read more
image01

Original Research Article | OPEN ACCESS

Formulation of keratin/HPMC matrix tablets for sustained delivery of diclofenac potassium for the management of inflammation

Ogochukwu Augustina Meko1 , Anisiobi Chiamaka1, Chukwunonso Onwuzuligbo1, Emmanuel Agbamu2, Vivian Nkechi Maduako3, Sylvester Okhuelegbe Eraga3, Matthew Ikhuoria Arhewoh3

1Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Chukwuemeka Odumegwu Ojukwu University, Igbariam, Anambra State; 2Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Delta State University, Abraka, Delta State; 3Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, University of Benin, Benin City, Nigeria.

For correspondence:-  Ogochukwu Meko   Email: oa.meko@coou.edu.ng   Tel:+234-7038611554

Received: 8 March 2025        Accepted: 20 May 2025        Published: 31 May 2025

Citation: Meko OA, Chiamaka A, Onwuzuligbo C, Agbamu E, Maduako VN, Eraga SO, et al. Formulation of keratin/HPMC matrix tablets for sustained delivery of diclofenac potassium for the management of inflammation. Trop J Pharm Res 2025; 24(5):583-590 doi: https://dx.doi.org/10.4314/tjpr.v24i5.2

© 2025 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..

Abstract

Purpose: To investigate the excipient properties of keratin/HPMC in sustained-release diclofenac matrix tablets.

Method: Tablets were prepared by wet granulation using different keratin/HPMC ratios. The granules were evaluated for pre-compression parameters such as flow properties, Hausner’s ratio, Carr’s index, while the matrix tablets were evaluated for post-compression parameters such as hardness, disintegration time, in-vitro drug release and release kinetics.

Results: There was no significant difference (p > 0.05) in flow properties and compression characteristics in formulations containing either keratin alone or in combination with HPMC. Furthermore, formulations containing keratin/HPMC in equal proportions exhibited better sustained release profiles (p < 0.05). The FTIR spectra revealed no change in the functional groups of diclofenac potassium.

Conclusion: Combination of keratin/HPMC improves the sustained release profile of diclofenac matrix tablets compared to either ingredient alone

Keywords: Keratin/HPMC polymer, Matrix tablet, Diclofenac, In vitro drug release

Impact Factor
Thompson Reuters (ISI): 0.6 (2023)
H-5 index (Google Scholar): 49 (2023)

Article Tools

Share this article with



Article status: Free
Fulltext in PDF
Similar articles in Google
Similar article in this Journal:

Archives

2025; 24: 
1,   2,   3,   4,   5. 
2024; 23: 
1,   2,   3,   4,   5,   6,   7,   8,   9,   10,   11,   12. 
2023; 22: 
1,   2,   3,   4,   5,   6,   7,   8,   9,   10,   11,   12. 
2022; 21: 
1,   2,   3,   4,   5,   6,   7,   8,   9,   10,   11,   12. 
2021; 20: 
1,   2,   3,   4,   5,   6,   7,   8,   9,   10,   11,   12. 
2020; 19: 
1,   2,   3,   4,   5,   6,   7,   8,   9,   10,   11,   12. 
2019; 18: 
1,   2,   3,   4,   5,   6,   7,   8,   9,   10,   11,   12. 
2018; 17: 
1,   2,   3,   4,   5,   6,   7,   8,   9,   10,   11,   12. 
2017; 16: 
1,   2,   3,   4,   5,   6,   7,   8,   9,   10,   11,   12. 
2016; 15: 
1,   2,   3,   4,   5,   6,   7,   8,   9,   10,   11,   12. 
2015; 14: 
1,   2,   3,   4,   5,   6,   7,   8,   9,   10,   11,   12. 
2014; 13: 
1,   2,   3,   4,   5,   6,   7,   8,   9,   10,   11,   12. 
2013; 12: 
1,   2,   3,   4,   5,   6. 
2012; 11: 
1,   2,   3,   4,   5,   6. 
2011; 10: 
1,   2,   3,   4,   5,   6. 
2010; 9: 
1,   2,   3,   4,   5,   6. 
2009; 8: 
1,   2,   3,   4,   5,   6. 
2008; 7: 
1,   2,   3,   4. 
2007; 6: 
1,   2,   3,   4. 
2006; 5: 
1,   2. 
2005; 4: 
1,   2. 
2004; 3: 
1. 
2003; 2: 
1,   2. 
2002; 1: 
1,   2. 

News Updates