Chika J Mbah¹, Chinwe M Onah¹ , Sardauna H Monde¹

¹Department of Pharmaceutical and Medicinal Chemistry, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka, Enugu State, Nigeria.

For correspondence:-  Chinwe Onah   Email: onah.chinwe@unn.edu.ng   Tel:+2347034195701

Received: 4 March 2025        Accepted: 21 July 2025        Published: 31 July 2025

Citation: Mbah CJ, Onah CM, Monde SH. Predicting cosolvents, surfactants and electrolytes as potential transdermal delivery enhancers of pantoprazole. Trop J Pharm Res 2025; 24(7):863-870 doi: https://dx.doi.org/10.4314/tjpr.v24i7.2

© 2025 The authors.
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Abstract

Purpose: To predict cosolvents, surfactants, and electrolytes as potential enhancers of pantoprazole transdermal delivery by examining their effects on the drug's coefficient of partition. Methods: At room temperature, the shake flask method was used in a chloroform-water system. The percent concentrations (% w/v) utilized in the study range from 0.0 - 25.0; 0.0 - 0.5 and 0.0 - 1.0 for cosolvents (glycerol, ethanol, propylene glycol, and polyethylene glycol 400); surfactants (Tween 20, Tween 80, sodium lauryl sulfate, and cetrimide); and electrolytes (NaCl, KCl, MgCl2, CaCl2, CdCl2, Na2SO4, K2SO4, MgSO4, AlCl3, and CoCl3), respectively. Established mathematical equations were utilized to calculate transdermal parameters. Results: Cosolvents, surfactants, and electrolytes reduced the logarithm partition coefficient of pantoprazole in comparison with control (distilled water). A significant difference (p < 0.05) occurred in the partition coefficient data of the drug between control and the vehicles/electrolytes investigated. Linear relationship was established between the logarithm partition coefficient and the logarithm estimated permeability coefficient of pantoprazole. Conclusion: Cosolvents, surfactants and electrolytes used are not to be considered potential transdermal delivery enhancers of pantoprazole.

Keywords: Pantoprazole, Partition coefficient, Transdermal delivery, Cosolvents, Surfactants, Electrolytes

Impact Factor
Thompson Reuters (ISI): 0.6 (2023)
H-5 index (Google Scholar): 49 (2023)