Elis Anggeria, Chrismis Novalinda Ginting , Tiarnida Nababan

Faculty of Nursing and Midwifery, Universitas Prima Indonesia, Medan, Indonesia;

For correspondence:-  Chrismis Ginting   Email: chrismis@unprimdn.ac.id

Received: 5 December 2025        Accepted: 19 March 2026        Published: 30 March 2026

Citation: Anggeria E, Ginting CN, Nababan T. Preparation of Moringa oleifera gel for the treatment of second-degree burns in a diabetic rat model. Trop J Pharm Res 2026; 25(3):289-295 doi: https://dx.doi.org/10.4314/tjpr.v25i3.1

© 2026 The authors.
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Abstract

Purpose: To determine the effectiveness of Moringa oleifera leaf extract in a gel preparation for treating second-degree burns in diabetic rat models. Method: The animals were divided into five groups labelled placebo, Bioplacenton®, and test preparations of 5, 10, and 15 % concentrations, respectively. Diabetes mellitus was first induced using intraperitoneal streptozotocin at a dose of 30 mg/kg BW and confirmed on the 3rd day; then, second degree burns were made on the backs of the animals. The 96 % ethanolic extract of mature Moringa oleifera was made into a gel. The placebo, Bioplacenton and gel preparations were then applied to the wounds of their labelled models. Wound healing was assessed through the healing rate based on the percentage decrease in wound diameter on the day of observation compared to the wound diameter the day after the wound was made. Results: There were statistically significant differences in wound healing rates among the groups (Bioplacenton, Placebo, 5, 10, and 15 %) treated with Moringa leaf gel on the 3rd, 6th, and 9th day (p < 0.05). There was no significant difference in healing rate among the 5 groups on the 12th and 14th day (p > 0.05). The average healing of second-degree burns occurred on the 14th day. Conclusion: Moringa leaves in gel preparations at 5, 10, and 15 % accelerate the healing process of second-degree burns in diabetic rat model.

Keywords: Extract, Moringa leaves, Gel, Burns, Degree II

Impact Factor
Thompson Reuters (ISI): 0.6 (2023)
H-5 index (Google Scholar): 49 (2023)