Mohammed Sattar^1,2 , Malathe Alshawi¹, Neven Nsaif Jasim¹

¹Department of Pharmaceutics, College of Pharmacy, University of Basrah,; ²College of Pharmacy, Al-Farqadein University College, Basrah, Iraq.

For correspondence:-  Mohammed Sattar   Email: mohammed.jabbar@uobasrah.edu.iq   Tel:009647729508962

Received: 24 March 2026        Accepted: 20 June 2026        Published: 29 June 2026

Citation: Sattar M, Alshawi M, Jasim NN. Effect of superdisintegrant type and concentration on dissolution behaviour of Ondansetron orodispersible tablets. Trop J Pharm Res 2026; 25(6):787-795 doi: https://dx.doi.org/10.4314/tjpr.v25i6.4

© 2026 The authors.
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Abstract

Purpose: To investigate the effect of various superdisintegrants on disintegration time and early-phase dissolution in ondansetron hydrochloride orodispersible tablets (ODTs). Methods: A total of 12 formulations were prepared by direct compression using a 3×4 full factorial design. Crospovidone (CPV), sodium starch glycolate (SSG), and croscarmellose sodium (CCS) were each tested at 2, 4, 6, and 8 % w/w. Primary responses were disintegration time, 5-minute drug release, dissolution similarity (f?), and Korsmeyer–Peppas exponent (n). Results: All blends had acceptable flow properties. At 8 % w/w, CPV released 77.2 % within 5 min compared to SSG (p < 0.01), f? = 45.3 between CPV and SSG indicated dissimilar profiles, and f? = 90.8 between SSG and CCS confirmed equivalent swelling-polymer behaviour. Korsmeyer–Peppas modelling gave n = 0.33 for CPV (Fickian diffusion) and n = 0.45, 0.44 for SSG and CCS, respectively, consistent with partial gel-layer resistance. Korsmeyer–Peppas rate constant showed kKP = 40.09 min-n for CPV compared to 7.13 min-n and 28.50 min-n for SSG and CCS, respectively. Furthermore, CPV produced faster early drug release compared to SSG and CCS at all concentrations. Conclusion: Crospovidone shows significantly superior early-phase dissolution at all concentrations compared with SSG and CCS

Keywords: Crospovidone, Korsmeyer–Peppas model, Ondansetron hydrochloride, Orodispersible tablets, Superdisintegrants

Impact Factor
Thompson Reuters (ISI): 0.6 (2023)
H-5 index (Google Scholar): 49 (2023)