Grace A Akpanika1 
,
Effiong E Nkanor2,
Frank I Archibong3
For correspondence:- Grace Akpanika Email: gakpanika@yahoo.com Tel:+2348034075133
Received: 18 February 2026 Accepted: 15 August 2026 Published: 31 August 2026
Citation: Akpanika GA, Nkanor EE, Archibong FI. Phytochemical profiling and identification of bioactive compounds in the leaf extract of Syzygium malaccense using Gas Chromatography–Mass Spectrometry. Trop J Pharm Res 2026; 25(8):1103-1107 doi: https://dx.doi.org/10.4314/tjpr.v25i8.7
© 2026 The authors.
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Purpose: To determine the phytochemical composition of methanol extract of Syzygium malaccense leaves using Gas Chromatography–Mass Spectrometry (GC–MS). Methods: Fresh leaves of Syzygium malaccense were air-dried, powdered and extracted with methanol using cold maceration. Following filtration and concentration under reduced pressure, the extract was freeze-dried and subjected to GC-MS to identify the phytochemicals present. Results: The analysis revealed the presence of thirty bioactive compounds with known medicinal and pharmacological properties. The identified compounds included phytol, oleic acid, copaene, caryophyllene and phenyltricyclo derivatives, all of which exhibit antioxidant, anti-inflammatory, antimicrobial, and anticancer properties. Conclusion: These results provide scientific support for the traditional uses of Syzygium malaccense and indicate the potential of the plant as a useful source of natural therapeutic agents.
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