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Original
Research Article
Antimicrobial Susceptibility of Community-associated
Staphylococcus aureus Isolates from Healthy Women in
Zaria, Nigeria
Adebola Onanuga1,
2
and Josiah
A Onaolapo1
1Department
of Pharmaceutics and Pharmaceutical Microbiology,
Faculty of
Pharmaceutical Sciences, Ahmadu Bello University, Zaria,
Nigeria; 2Department of Pharmaceutical
Microbiology and Biotechnology, Faculty of Pharmacy,
Niger Delta University, Wilberforce Island, Amasoma,
Bayelsa State, Nigeria.
Tropical
Journal of Pharmaceutical Research, March
2008; 7(1):
929-934
Abstract
Purpose:
An investigation of the antimicrobial susceptibility
patterns of Staphylococcus aureus isolated from healthy
women to ten commonly used antimicrobial drugs
was carried out
as a basis
for a guide for empirical antimicrobial treatment using
urine samples.
Method:
The samples collected from healthy women volunteers in
Zaria were cultured and screened for S. aureus using
standard microbiological procedures. The antimicrobial
susceptibility of the isolates was investigated using
disc diffusion technique.
Result:
A total of 54(36%) S. aureus isolates were isolated from
150 urine samples collected. Of the 54 isolates, 16
(29.6%), 15 (27.8%) and 23 (42.6%) were from married but
not pregnant, pregnant and single women respectively.
The isolates were highly susceptible to ciprofloxacin,
gentamicin, ofloxacin, sparfloxacin and pefloxacin in
both groups (married and single). The differences
observed in all the antimicrobial drugs tested for both
groups were not statistically significant (p>0.05). A
total of 34 (63%) of the isolates showed multi-drug
resistance and only 6 (11%) were susceptible to all the
antimicrobial drugs tested.
Conclusion:
This observation calls for measures to reduce the
reservoir of antimicrobial resistant organisms in
healthy populations.
Key words:
Antimicrobial drugs, community-associated,
susceptibility, Staphylococcus aureus, healthy women. |
