Report

 

In vitro Antimicrobial Activity of the Extract of Mitracarpus scaber Leaves Formulated as Syrup

 

TA Abere^1*, AO Onyekweli², and GC Ukoh³

¹Department of Pharmacognosy. ²Department of Pharmaceutics and Pharmaceutical Technology. ³Department of Pharmaceutical Microbiology. Faculty of Pharmacy, University of Benin, PMB 1154, Benin-City, Nigeria

 

Tropical Journal of Pharmaceutical Research 2007; 6(1): 679-682

ISSN: 1596-599

 

Abstract

Purpose: To formulate the crude extract of the leaves of Mitracarpus scarber “Zucc” as a syrup.

Method: The antimicrobial activity of the formulation was assessed using agar plates and concentrations of the extract varying between 25mg/ml and 300mg/ml to determine the minimum inhibitory concentration at 37^oC against bacterial and fungal organisms namely, Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Sarcina lutea, Candida albicans and Klebsiella pneumoniae.

Result: The growth of Escherichia coli, Staphylococcus aureus, Klebsiella pneumoniae and Candida albicans was inhibited by the formulation at a minimum inhibitory concentration of 75mg/ml. Pseudomonas aeruginosa, and Sarcina lutea resisted all the concentrations of the formulation used. The presence of sucrose in the formulation rendered the formulation pleasant to taste.

Conclusion: The extract from the leaves of Mitracarpus scarber “Zucc” can be formulated into a pleasantly tasting oral dosage form despite its bitter taste.

Keywords: Antimicrobial, Mitracarpus scaber, syrup, formulation, minimum inhibitory concentration.