Preparation of
Mucoadhesive Patches for Buccal Administration of
Metoprolol Succinate: In Vitro and In Vivo
Drug Release and Bioadhesion
Navneet Verma1,2* and Pronobesh
Chattopadhyay3
1College
of Pharmacy, IFTM University, Moradabad-244001 (U.P.),
2Institute of Pharmacy, Bhagwant University,
Ajmer-305004 (Raj.), 3Defence Research
Laboratory, Tejpur-784001 (Assam), India
For correspondence:
Email:
navneet28jan@yahoo.com Tel:
+91-9917731198
Received: 15 May
2011 Revised
accepted: 14 December 2011
Tropical
Journal of Pharmaceutical Research, February 2012;
11(1): 9-17
http://dx.doi.org/10.4314/tjpr.v11i1.2
Abstract
Purpose:
To develop mucoadhesive patches for buccal
administration of metoprolol succinate and to evaluate
their in vitro and in vivo bioadhesion.
Methods:
The mucoadhesive buccal patches were prepared by solvent
casting technique using two different mucoadhesive
polymers. The formulations were tested for in vitro drug
permeation studies, buccal absorption, in vitro drug
release studies, moisture absorption as well as for in
vitro and in vivo bioadhesion.
Results:
The peak detachment force and work of adhesion for MC5
(sodium carboxymethylcellulose, i.e., Na CMC) patch were
0.87 N and 0.451 mJ respectively and the corresponding
values for CH5 (chitosan) were 5.15N and 0.987 mJ.
Formulation CH5 (prepared with chitosan) showed 67.1 %
release, while MC5 (Na CMC) showed drug release of 81.9
% in 6 h. Basic pharmacokinetic parameters such as Cmax,
Tmax and AUCtotal varied
statistically (p < 0.05) when given by the buccal route
compared with that of the solution given by the oral
route.
Conclusion:
The results indicate that formulation of suitable
bioadhesive buccal patches with the desired permeability
is feasible. The development of bioadhesive buccal
formulation for metoprolol succinate with a lower dose
and few side effects may be attainable.
Keywords:
Mucoadhesive, Buccal patches, Metoprolol succinate,
Sodium carboxymethylcellulose, Chitosan, Bioavailability.
