http://dx.doi.org/10.4314/tjpr.v11i5.2
Abstract
Purpose:
To
develop an oral capsule-based chronomodulated drug
delivery system of salbutamol sulphate for the treatment
of nocturnal asthma.
Methods: The basic design of the proposed
dosage form entails an insoluble cross-linked capsule
body filled with drug-loaded pellets sealed with
hydrocolloid plug and a soluble capsule cap. Various
hydrocolloid polymers, namely, hydroxypropyl
methylcellulose, (HPMC), hydroxypropyl cellulose (HPC),
sodium alginate, polyethylene oxide (PEO) and guar gum.
were used to optimize the plug material in the delivery
in order to modulate lag period To avoid gastric transit
time variability, the entire system was coated with
Eudragit S100/Eudragit L100 dispersion (4:1), an enteric
polymer system that dissolves at pH 6.8.
Results: Time-specific pulsatile release with
4 h lag period was achieved with crosslinked insoluble
gelatin capsule shells containing pellets prepared from
Avicel PH 101/lactose (80: 10) and 3 % Acidisol as
disintegrant. In vitro data indicate that the developed
pulsatile system released almost 98 % of the drug
shoertly after the predetermined lag time of 4 h.
Conclusion: The developed system is capable of
releasing the drug after a 4-h lag period. However, in
vivo studies need to be carried out to ascertain the
effectiveness of the formulation.
Keywords: Time controlled, pH-controlled, Lag
time, pulsed release, Hydrocolloid plug, Nocturnal
asthma
