Antidiabetic, Antihyperlipidemic and Antioxidant
Activities of Buchanania lanzan Spreng Methanol Leaf
Extract in Streptozotocin-Induced Types I and II
Diabetic Rats
N Sushma1, P
Venkata Smitha2, Y Venu Gopal1, R
Vinay1, N. Srinivasa Reddy1, Ch
Murali Mohan2 and A Butchi Raju1*
1St. Peter’s Institute of
Pharmaceutical Sciences, Warangal-506001, 2Department
of Biotechnology, Gitam Institute of Technology, Gitam
University, Visakhapatnam, 530045, India
*For correspondence: E-mail:
drraju2020@gmail.com
Received: 17 July
2012
Revised accepted:
19 February 2013
Tropical
Journal of Pharmaceutical Research, April 2013;
12(2): 221-226
http://dx.doi.org/10.4314/tjpr.v12i2.14
Abstract
Purpose:
To
evaluate the antidiabetic, antihyperlipidemic and
antioxidant activities of Buchanania lanzan.
Methods: Wistar rats were divided into nine
groups of six animals each, and 40 mg/kg of
streptozotocin or streptozotocin + nicotinamide was
administered intraperitonially to induce types I and II
diabetes. Those with blood glucose levels > 190 ± 8
mg/dl were administered the methanol leaf extract of
Buchanania lanzan (MEBL, 100 or 200 mg/kg, p.o.) or
positive control for 21 days. Blood glucose, lipid
profile, antioxidant enzymes and oxidative stress
markers were evaluated.
Results: Following induction, blood glucose
level rose to
327.7 ± 47.4 mg/dl, compared to the normal value of
910 ± 3.2
mg/dl. Administration of MEBL (100 or 200 mg/kg) significantly (p <
0.05) decreased blood glucose level, serum lipid
profile, and significantly (p < 0.05) increased
antioxidant activity as evidenced by increase in super
oxide dismutase (SOD), catalase, glutathione (GSH), and
decrease in the activity of lipid peroxidation (LPO).
Conclusion:
MEBL exhibits antidiabetic, antihyperlipidemic and
antioxidant activities in diabetic rat and needs to be
further investigated for the treatment of both types I
and II diabetes mellitus.
Keywords:
Antidiabetic, Antihyperlipidemic, Antioxidant,
Buchanania lanzan.
