Comparative Analgesic and
Anti-inflammatory Activities of Two Polyherbal Tablet
Formulations (Aujaie and Surangeen) in Rats
MS Akhtar1, A
Malik1, MS Saleem1 and G Murtaza2*
1Faculty of Pharmacy,
University of Sargodha, Sargodha, 2Department
of Pharmaceutical Sciences, COMSATS Institute of
Information Technology, Abbottabad 22060, Pakistan.
*For correspondence:
Email:
gmdogar356@gmail.com Tel:
+92-314-2082826; Fax: +92-992-383441
Received: 17 July 2012
Revised accepted: 26 June
2013
Tropical Journal of
Pharmaceutical Research, August 2013; 12(4):
603-607
http://dx.doi.org/10.4314/tjpr.v12i4.24
Abstract
Purpose: To investigate the analgesic and
anti-inflammatory activities of two herbal polymedicines
- Aujaie and Surangeen to ascertain their therapeutic
claims.
Methods: A total of 96 rats were divided into
two equal groups; one for determination of
anti-inflammatory activity and the other for analgesic
activity. Anti-inflammatory and analgesic activities
were evaluated by carrageenan-induced paw edema and
formalin-induced paw licking test, respectively. For
both studies, group I (untreated control) received 1
ml/kg, (po) of gum suspension 1 h before carrageenan
injection. Aspirin (100 mg/kg, po) was given to group II
(treated control) before injection. Groups III, IV and V
were administered orally aujaie (3, 4 and 5 mg/kg, po,
respectively), while surangeen tablets (10, 20 and 40
mg/kg, po) were given to groups VI, VII and VIII,
respectively. Pain was experimentally induced by
injecting 0.1 ml of 2.5 % formalin (40 % formaldehyde in
distilled water) via the subplantar region of the left
hind paw.
Results: Significant (p < 0.05)
anti-inflammatory activity for aspirin (group II as well
as for groups III - VIII with paw edema inhibition (PDI)
ranging from 24.6 - 90.2 %, There was significant ((p <
0.05) analgesic activity in group II, VI and VII while
in groups III - V and VIII the activity was
insignificant (p < 0.05).
Conclusion: Aujaie and surangeen tablets
exhibited pronounced analgesic and anti-inflammatory
activities in rats depending on the dose employed.
Keywords: Aujaie, Surangeen,
Anti-inflammatory, Analgesic.
