In Vitro
and In Vivo
Evaluation of Diclofenac Sodium Gel Prepared with
Cellulose Ether and Carbopol 934P
Dheeraj T Baviskar1*,
Yogeshkumar A Biranwar1, Kapil R Bare1,
Venkatesh B Parik1, Mangesh K Sapate1
and Dinesh K Jain2
1Department of Pharmaceutics,
Institute of Pharmaceutical Education, Boradi, 425 428,
Tal-Shirpur, (M.S.), 2Department of
Pharmaceutics, College of Pharmacy, IPS Academy, Indore,
452 012 (M.P.), India.
*For correspondence:
Email:
baviskar@sancharnet.in Tel:
+919850001942
Received: 14 July 2012
Revised accepted: 12 June
2013
Tropical Journal of
Pharmaceutical Research, August 2013;
12(4): 489-494
http://dx.doi.org/10.4314/tjpr.v12i4.7
Abstract
Purpose: To develop diclofenac
sodium gel using high molecular weight hydroxypropyl
methylcellulose (HPMC) and Carbopol 934P for topical and
systemic delivery.
Methods:
Diclofenac sodium gel was
prepared with HPMC K100M and Carbopol 934P as gelling
agents. The formulations were examined for pH,
spreadability, consistency, viscosity, homogeneity, drug
content and stability. In vitro drug release was
evaluated using Franz diffusion cell. Carrageenan-induced
rat paw oedema model was used for the evaluation of the
anti-inflammatory activity of the gels. A commercial
diclofenac sodium gel product was used as the reference
drug.
Results: Formulations containing
glycerin as permeation enhancer gave drug release
patterns comparable to that of the reference product.
The drug content of F2, F5 and F9
was 99.81, 99.75 and 99.96 %, respectively. Accelerated
stability results showed no significant variation in the
appearance and drug release after storage for 3 months.
Conclusion: Diclofenac sodium gel
containing HPMC K100M and Carbopol 934P exhibited
pronounced anti-inflammatory activity and could be
further developed for topical and systemic delivery..
Keywords: Diclofenac
sodium, Anti-inflammatory, Hydroxypropyl
methylcellulose, Carbopol, Drug release, Glycerin.
