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Original Research Article
Evaluation of prophylactic
Effect of Remifentanil on Succinylcholine-Induced
Myalgia in Humans
Karim Nasseri1*,
Mehdi Taibi Arasteh2, Abdorrahim Afkhamzadeh3
and Saeed Hakhamaneshi4
1Department of Anesthesia and
Intensive Care, Kurdistan Research Center for Social
Determinants of Health, (KRCSDH), School of Medicine,
2Department of Anesthesia and Intensive Care,
3Department of Community Medicine, Kurdistan
Research Center for Social Determinants of Health, (KRCSDH),
4Department of Microbiology, Kurdistan
University of Medical Sciences, Sanandaj, Iran
*For correspondence:
Email:
nasseri_k@muk.ac.ir; Tel:
00988716660733; Fax: 00988713285890
Received: 28 January 2013
Revised accepted: 18
October 2014
Tropical
Journal of Pharmaceutical Research, December 2014;
13(12):
2027-2030
http://dx.doi.org/10.4314/tjpr.v13i12.12
Abstract
Purpose: To assess the efficacy of
remifentanil in preventing succinylcholine-induced
myalgia in humans.
Methods: Sixty healthy adults
scheduled for elective surgery under general anesthesia
were enrolled in a double-blind study and randomly
allocated to two groups of thirty patients. Patients in
Group I (remifentanil group) were pretreated with
remifentanil 1 μg/kg one minute prior to induction of
anesthesia, while patients in Group II (saline group)
received an equivalent volume of saline. Anesthesia was
induced in both groups with fentanyl 1 μg/kg, propofol
2.0 mg/kg and succinylcholine 1.5 mg/kg. Postoperative
myalgia was assessed 12, 24, and 48 h after induction
and graded as nil, mild, moderate, or severe.
Results: Fifty nine patients
completed the study. The demographic data for both
groups were comparable (p > 0.05). Postoperative myalgia
at 12, 24, and 48 h after induction were 34.5, 34.5 and
14.1 % in group I, and 60, 53.4 and 30 % in group II,
respectively (p > 0.05).
Conclusion: Prophylactic use of
remifentanil 1 μg/kg intravenously is ineffective in the
prevention of postoperative myalgia
Keywords: Remifentanil,
Succinylcholine, Myalgia, Propofol, Prophylaxis |
