Purpose: To assess the effect of occupational factors on quality of life (QOL) of workers in Governmental and non-Governmental sectors in southeastern Nigeria.

Methods: A total of 2025 workers (both governmental and non-governmental sectors) were selected from across five southeastern states of Nigeria by convenient sampling. The Medical Outcomes Survey Short Form-36 (SF-36) alongside twenty closed questions was administered to the two groups of respondents to assess their quality of life and determine other factors that affected their quality of life.

Results: Having a job that is tasking (r = -0.209, p < 0.05) contributed significantly to low Physical Component Summary (PCS ) in non-governmental sector but having job that raises enough finances for one’s comfort (r = 0.228, p < 0.05) impacted positively on their PCS. Being overly stressed by the job (r = -0.225, p < 0.01) was the only factor that significantly impacted negatively on Mental Component Summary (MCS) of respondents in Governmental sector while having a job that exposes one to a lot of health risk (r = -0.269, p < 0.01, having a job that is tasking (r = -0.206, p < 0.05) and having the belief that there are spiritual forces responsible for the challenges one is facing (r = -0.249, p < 0.05) accounted for decrease in MCS of respondents in non-Governmental sector.

Conclusion: Occupational factors had more negative impact on the quality of life of respondents in non-Governmental sector than their counterparts in Governmental sector of the economy.