Tropical Journal of Pharmaceutical Research

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Original Research Article

Physicochemical Characterization and Dissolution Studies of Solid Dispersions of Clotrimazole with Pluronic F127

Bożena Karolewicz¹*, Maciej Gajda¹, Artur Owczarek¹, Janusz Pluta¹ and Agata Górniak²

¹Department of Drug Form Technology, ²Department of Inorganic Chemistry, Wroclaw Medical University, Borowska 211A, 50-556 Wroclaw, Poland

*For correspondence: Email: maciej.gajda@umed.wroc.pl; Tel: +48 71 78 40 554; Fax: +48 71 78 40 317

Received: 4 April 2014 Revised accepted: 1 July 2014

Tropical Journal of Pharmaceutical Research, August 2014; 13(8): 1225-1232

http://dx.doi.org/10.4314/tjpr.v13i8.5

Abstract

Purpose: To evaluate the physicochemical properties of clotrimazole (CLT) solid dispersion with Pluronic F127 (PLU).

Methods: Solid dispersions of the antifungal drug, clotrimazole, were prepared with Pluronic F127 using grinding (PM) and fusion (FUS) methods. Physicochemical characterization of the dispersions were performed using differential scanning calorimetry (DSC), x-ray powder diffraction (XRPD) and Fourier transform infrared spectroscopy (FTIR). In vitro drug release was carried out using the rotating disc method.

Results: These studies showed that there was no chemical interaction between CLT and PLU. Release studies on the SDs showed a significant (> 90-fold) improvement in dissolution rate compared to pure CLT. The greatest increase in dissolution (< 80 %) was observed for the solid dispersion (CLT/PLU) prepared by FUS in the ratio 60:40 % w/w.

Conclusion: The results demonstrate that the developed solid dispersion system is a suitable approach for enhancing the dissolution rate of CLT.

Keywords: Clotrimazole, Pluronic F127, Solid dispersion, Dissolution, Differential scanning calorimetry, Phase diagram