Coordination Compounds of M(II) Biometal Ions with Acid-Type Anti-inflammatory Drugs as Ligands – A Review

Nenad S Krstić¹, Ružica S Nikolić¹, Maja N Stanković¹, Nada G Nikolić² and Dragan M Đorđević¹

¹Department of Chemistry, Faculty of Sciences and Mathematics, University of Niš, Višegradska 33, ²Medical Faculty, University of Niš, Bulevar Dr Zorana Đinđića 81, 18000 Niš, Serbia

*For correspondence: Email: nenad.krstic84@yahoo.com; Tel: +38118514882

Received: 14 August 2014                                                                     Revised accepted: 16 January 2015

http://dx.doi.org/10.4314/tjpr.v14i2.21   

Abstract

The cations of biometals in biological systems easily interact with various moieties of organic and inorganic biomolecules, either as natural constituents or after introduction into the body via O-, N- and S- donor atoms. Study of the interaction between M(II) biometal–O-donor ligand (drug) is of interest for various reasons: more evenly dosing of medicine and biodistribution of medicine; monitoring of its pharmacokinetics including excretion; reduction of unwanted effects of the medicine; greater antimicrobial activity; synergistic effect of the metal and medicine; and improved anti-ulcerous, anti-tumor and anti-bacterial activity. This paper offers an overview of the literature of published research on coordination between biometals and anti-inflammatory drugs of the acid type. The metals that the subject of focus in this review are d-metals with M(II) ions, namely, copper (Cu), zinc (Zn), cobalt (Co) and manganese (Mn).Those containing molecules with carboxyl functional groups can build complexes with coordinated number of metals of 4 and 6, of various stoichiometric structures, simple or complex, and also behave as monodentate, bidentate or bridge ligands in polynuclear complexes.