Some Physical Characteristics of Microcrystalline Cellulose Obtained from Raw Cotton of Cochlospermum planchonii

Ohwoavworhua, F.O.* and Adelakun, T.A

Department of Pharmaceutical Technology and Raw Materials Development (PT&RMD), National Institute for Pharmaceutical Research and Development, (NIPRD), P.M.B. 21, Abuja, Nigeria

 

Tropical Journal of Pharmaceutical Research 2005; 4(2): 501-507

ISSN: 1596-5996

 

Abstract

Purpose: The microcrystalline cellulose is an important ingredient in pharmaceutical, food, cosmetic and other industries. This study aimed at evaluating the physical characteristics of microcrystalline cellulose (CP-MCC), obtained from the raw cotton of Cochlospermum planchonii.

Methods: CP-MCC was obtained from the raw cotton by a two-stage sodium hydroxide treatment process followed by sodium hypochlorite bleaching and acid hydrolysis. It was examined for its physicochemical and powder properties. The powder properties of CP-MCC were compared to those of the well-known commercial microcrystalline cellulose grade, Avicel PH 101.

Results: The extraction yield of CP-MCC was approximately 21%. The cellulose material was composed of irregularly shaped fibrous cellulose particles with a moisture content of 7.2% and total ash of 0.12%. The true density was 1.38. The flow indices showed that CP-MCC has poor flow.  The hydration, swelling and moisture sorption capacities were 4.7, 83.3 and 22%, respectively.

Conclusion: The cellulose product, CP-MCC, obtained from the raw cotton of Cochlospermum planchonii conformed to the official specifications in the British Pharmacopoeia (2004). The flow properties of a powder are critical in direct compression tableting; consequently, for the materials to be used for this purpose, it would require the addition of a glidant. Furthermore, the swelling parameters indicate that CP-MCC would be a better disintegrant than Avicel PH 101.

Keywords: Cochlospermum planchonii, microcrystalline cellulose, physical characteristics, pharmacopoeial requirements

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