Nanoparticles - A review

V.J. Mohanraj^1* and Y. Chen²

¹Orchid Chemicals & Pharmaceuticals Limited, Chennai, India

² School of Pharmacy, Curtin University of Technology, Perth, Australia

 

Tropical Journal of Pharmaceutical Research 2006; 5(1): 561-573

ISSN: 1596-5996

 

Abstract

 

For the past few decades, there has been a considerable research interest in the area of drug delivery using particulate delivery systems as carriers for small and large molecules. Particulate systems like nanoparticles have been used as a physical approach to alter and improve the pharmacokinetic and pharmacodynamic properties of various types of drug molecules. They have been used in vivo to protect the drug entity in the systemic circulation, restrict access of the drug to the chosen sites and to deliver the drug at a controlled and sustained rate to the site of action. Various polymers have been used in the formulation of nanoparticles for drug delivery research to increase therapeutic benefit, while minimizing side effects. Here, we review various aspects of nanoparticle formulation, characterization, effect of their characteristics and their applications in delivery of drug molecules and therapeutic genes. 

Key words: nanoparticles, drug delivery, targeting, drug release

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