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Original
Research Article
Characterization of
glipizide-loaded polymethacrylate microspheres prepared
by an emulsion solvent evaporation method
BC Behera*a,
SK Sahooa, S Dhala, BB Barika,
BK Guptab
aUniversity
Department of Pharmaceutical Sciences, Utkal University,
Vani-Vihar, Bhubaneswar, Orissa. Pin- 751004.
bDept.
of Pharmaceutical Technology, Jadavpur University
Kolkata, India
Tropical
Journal of Pharmaceutical Research, March
2008; 7(1):
879-885
Abstract
Purpose:
The purpose of the present investigation was to
formulate and evaluate microencapsulated glipizide
produced by the emulsion – solvent evaporation method,
Method:
Microspheres were prepared using
polymethacrylate polymers (Eudragit® RS 100
and RL 100) by solvent evaporation method and
characterized for their micromeritic properties and drug
loading, as well as by Fourier transform infrared
spectroscopy (FTIR) and scanning electron microscopy. In
vitro release studies were performed in phosphate buffer
(pH 7.4).
Result:
The resulting microspheres obtained by solvent
evaporation method were white and free flowing in
nature. The mean particle size of microspheres ranged
from 420 - 660
mm and the
encapsulation efficiencies ranged from 40.27 - 86.67 %.
The encapsulation efficiency was also found to be
dependant on nature of polymer used in the formulation.
The infrared spectra confirmed the stable character of
glipizide in the drug-loaded microspheres. Scanning
electron microscopy revealed that the microspheres were
spherical in nature. From the in vitro drug dissolution
studies it was found that the sustaining effect of
microspheres depended on the polymer concentration,
amount of dispersant used and the type of polymer used
in the formulation. The mechanism of drug release from
the microspheres was found to be non-Fickian type.
Conclusion:
Eudragit® microspheres containing glipizide
could be prepared successfully by using an emulsion
solvent evaporation technique using polymethacrylate
polymers, which will not only sustain the release of
drug but also manage the complicacy of the diabetes in a
better manner.
Keywords:
glipizide, Eudragit®, microspheres,
controlled release, polymethacrylate. |
