Anti-ulcer and anti-inflammatory effects of
hydro-alcohol extract of Aloe buettneri
A. Berger (lilliaceae)
K Metowogo, A Agbonon, K
Eklu-Gadegbeku, AK Aklikokou and M Gbeassor*
Centre de Formation et de Recherche
sur les Plantes Médicinales (CERFOPLAM), Laboratoire de
Pharmacologie-Physiologie, Faculté des Sciences.
Université de Lomé-Togo.
Abstract
Purpose:
Aloe buettneri A. Berger is commonly
used in Togolese folk medicine to treat inflammation and
gastric ulcer. In this study we investigated the
anti-oedema, analgesic, antipyretic and ulcer healing
properties of the hydro-alcohol extract of their
leaves.
Methods:
Rat oedema paw were induced by the
injection of 0.1 ml of
formaldehyde 1%, tail flick method is used to study
analgesic property, hyperthermia was induced by
subcutaneous injection of 15% of a brewers' yeast
suspension at dose of 10 ml/kg and ulcers were induced
by ethanol or HCl/ethanol mixture.
Results:
The extract showed anti-inflammatory
properties at doses between 250-500 mg/kg. It
inhibited, in a dose- dependent manner, the oedema
induced by 0.1 ml of formaldehyde 1%. Scores of 73.70%
and 83.63% were obtained when the doses of extract
administered were 100 and 500 mg/kg, respectively. The
tail flick analgesic index showed an increase of 36.56%
when the dose was 500 mg/kg. The extract decreased
significantly the hyperthermia induced by the injection
of yeast. 1000 mg/kg of the extract inhibited 63.77% of
the gastric lesion induced by acid-water-ethanol mixture
while daily administration of the same dose accelerated
the cicatrisation
of gastric ulcer induced by 95% ethanol.
Conclusion:
The results obtained show that
the hydro-alcohol extract of Aloe buettneri A.
Berger (Lilliaceae) has
anti-inflammatory, anti-ulcer and wound healing
properties
Keywords:
Aloe
buettneri,
oedema, analgesic, hyperthermia, ulcer.
