Tropical Journal of Pharmaceutical Research

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Review Article

Chemical Penetration Enhancers for Transdermal Drug Delivery Systems

Inayat Bashir Pathan¹*, C Mallikarjuna Setty²

¹Department of Pharmaceutics, M.E.S College of Pharmacy, Sonai. Maharashtra, ²Department of Pharmaceutics, Sarasvati College of Pharmacy, Moniabad, Andhra Pradesh, Indian. E-mail: inayat.p78631@rediffmail.com Tel: 09921227045 / 09325137058

Received: 22 November 2007 Revised accepted: 29 November 2008

Tropical Journal of Pharmaceutical Research, April 2009; 8(2): 172-179

Abstract

Skin as an important site of drug application for both local and systemic effects. However in skin, the stratum corneum is the main barrier for drug penetration. Penetration enhancement technology is a challenging development that would increase the number of drugs available for transdermal administration. The permeation of drug through skin can be enhanced by both chemical penetration enhancement and physical methods. In this review, we have discussed the chemical penetration enhancement technology for transdermal drug delivery as well as the probable mechanisms of action.

Keyword: Transdermal delivery; skin; chemical penetration enhancers.