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Original
Research Article
Dose-Dependent
Amelioration of Gentamicin-Induced Nephrotoxicity in
Adult Swiss Albino Rats by Vitamin B-complex - A
Preliminary Study
Shaibu O Bello1,2* and Aminu Chika1
1Department
of Pharmacology, College of Health Sciences, Usmanu
Danfodiyo University, 2Fertility Unit, Karaye
Hospital, Emir Yahaya Road, Sokoto, Nigeria.
E-mail: bellooricha@yahoo.com
Tel: +234-(0)8066024503
Received:
23 June 2008
Revised accepted:
8 December 2008
Tropical
Journal of Pharmaceutical Research, April
2009; 8(2):
111-116
Abstract
Purpose:
To evaluate the effect of vitamin B-complex on the
nephrotoxicity of gentamicin in an established rat
model.
Methods:
Adult Swiss albino rats weighing 170±20g were divided
into 4 groups of 4 rats each. Each group was given one
of the following: placebo injection (Control), 80mg/kg
of gentamicin sulphate alone or with 1.5ml/kg/3ml/kg
body weight of vitamin B-complex (intramuscular)
containing 10mg thiamine, 1.5mg riboflavin and 1.0mg
pyridoxal-6-phosphate per ml.
Results:
In the Swiss albino rats, daily intramuscular 80mg/kg
gentamicin sulphate significantly (p<0.05) and
consistently produced biochemical signs of
nephrotoxicity after 5 days. Also, 1.5 ml/kg of
B-complex significantly (p<0.05) ameliorated the rate
and extent of increase in serum urea and creatine while
3ml/kg of the same drug completely prevented the
increase in serum urea and creatine in this model.
Conclusion:
Vitamin B-complex dose-dependently ameliorated
gentamicin-induced nephrotoxicity in adult Swiss albino
rats when given intramuscularly. This finding may have
important clinical utility.
Keywords:
Gentamicin, B-complex, Swiss albino rats, Nephrotoxicity,
Serum urea and creatine. |
