Indexed by Science Citation Index (SciSearch), International Pharmaceutical Abstract, Chemical Abstracts, Embase, Index Copernicus, EBSCO, African Index Medicus, JournalSeek, Journal Citation Reports/Science Edition, Directory of Open Access Journals (DOAJ), African Journal Online, Bioline International, Open-J-Gate

ISSN: 1596-5996 (print); 1596-9827 (electronic)-

Home | Back Issues | Current Issue | Review manuscript | Submit manuscript


	This Article
	Abstract
	Full-text
	Table of contents
	Comments
	Letters
	Comments to Editor

	e-mail Alert
	Sign Up

Research Article

Microencapsulation of Diclofenac Sodium by Non-solvent Addition Technique

G Murtaza¹, M Ahmad^1* and G Shahnaz²

¹Department of Pharmacy, Faculty of Pharmacy and Alternative Medicines, The Islamia University of Bahawalpur, Bahawalpur 63100, Pakistan, ²Department of Pharmaceutical Sciences, Faculty of Pharmacy, University of Innsbruck, Austria.

*Corresponding author: E-mail: gmdogar356@gmail.com Tel: +92-300-9682258 (mobile), 62-9255243; Fax: +92-62-9255565

Received: 26 July 2009 Revised accepted: 21 January 2010

Tropical Journal of Pharmaceutical Research, April 2010; 9(2): 187-195

Abstract

Purpose: To prepare, using non-solvent addition technique, diclofenac sodium-ethylcellulose microparticles with modified drug release properties.

Methods: Microparticles were prepared by non-solvent addition phase separation method and characterized by micromeritics, scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), x-ray diffraction (XRD), dissolution test and thermal analysis.

Results: The microparticles were whitish, irregular, aggregated, and in the size range of 390 - 442 µm size. Drug embedment efficiency was 89 - 91 %. Characterisation studies indicate that there was no strong chemical interaction between the drug and the polymer in the microparticles. Polymer concentration and sustained release behavior were directly proportional.

Conclusion: Non-solvent addition phase separation is a suitable method for preparing diclofenac sodium-ethylcellulose multi-unit controlled release drug delivery system.

Keywords: Phase separation, Diclofenac sodium, Ethylcellulose, Non-solvent addition, Characterisation.