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Research
Article
Effect
of Cream Formulation of Fenugreek Seed Extract on Some
Mechanical Parameters of Human Skin
N Akhtar1, MK
Waqas1, M Ahmed1, T Saeed2,
G Murtaza1*, A Rasool1, MN Aamir1,
SA Khan1, NS Bhatti3 and A Ali3
1Department
of Pharmacy, Faculty of Pharmacy and Alternative
Medicines, The Islamia University of Bahawalpur,
Bahawalpur 63100, 2College of Pharmacy, The
University of the Punjab, Lahore, 3Department
of Pharmacy, the University of Faislabad, Faisalabad,
Pakistan.
*Corresponding author:
E-mail:
gmdogar356@gmail.com Tel:
+92-3142082826; Fax: +92-629255565
Received: 20 January
2010
Revised accepted: 8 June 2010
Tropical
Journal of Pharmaceutical Research, August 2010;
9(4):
329- 337
Abstract
Purpose:
To determine the effect of an emulsion formulation of
fenugreek (Trigonella Foneum-Graecum L) seed extract on
some mechanical parameters of the skin of healthy human
volunteers
Methods:
A water-in-oil emulsion cream base without fenugreek
seed extract which served as control, and a similar
formulation containing 4 %w/v of the extract in the
internal (aqueous) phase were prepared. Each of the
formulations was applied to the cheeks of 10 human
volunteers for a period of 4 weeks and some mechanical
parameters (R0, R1, R2, R3, R4, R5, R6, R7, R8 and R9)
of the skin were measured weekly using Cutometer MPA
580.
Results:
The results indicate that the effects of the creams on
skin mechanical properties were significant (p < 0.05)
with respect to time, except for R4 and R9. The
extract-containing cream substantially increased skin
elasticity, hydration and the ability of skin to resist
photo-aging when compared to the base.
Conclusion:
Both the cream base and the cream containing fenugreek
extract demonstrated significant (p < 0.05) improvement
in all mechanical parameters related to skin elasticity,
ageing, hydration and fatigue but the effect of the
extract cream was more pronounced in some cases.
Keywords:
Cutometer, Fenugreek seed extract, Skin elasticity, Skin
ageing, Skin hydration . |
