Diuretic Activity of Rubus idaeus L (Rosaceae) in
Rats
Ying Zhang, Zhenya Zhang*,
Yinnan Yang, Xiaoyan Zu, Di Guan and Yuepeng Wang
Graduate School of Life and Environmental Sciences,
University of Tsukuba, 1-1-1, Tenoudai, Tsukuba,
Ibaraki, 305-8572, Japan
For correspondence:
E-mail:
tyou6688@sakura.cc.tsukuba.ac.jp
Tel:
+81-29-853-4712
Received: 2 February
2011
Revised accepted: 14 May 2011
Tropical
Journal of Pharmaceutical Research, June 2011;
10(3):
243-248
doi:
10.4314/tjpr.v10i3.15
Abstract
Purpose:
To evaluate the
diuretic activity of Rubus idaeus L in experimental
rats.
Methods:
Hot-water and methanol extract of three kinds of Rubus
idaeus L. fruits were administered to experimental rats
orally at a dose of 2 and 5 mg/kg. Hydrochlorothiazide
(10 mg/kg) was used as positive control in study. The
diuretic effect of the extracts was evaluated by
measuring urine volume, sodium and potassium excretion
in the urine.
Results:
Compared with the control group, significant increase in
urine volume was observed from the experimental animal
treated with wild raspberry methanol extract. In
addition, we find that the methanol extract of wild
raspberry fruits shows a potassium-conservation diuretic
effect, which is a very interesting property in a
phytodiuretic.
Conclusion:
Methanol
extract of wild raspberry fruits have diuretic effect on
experimental rats. This might be the first formal
reports on diuretic effect of raspberry fruits, which
can also, to some extent, explain the use of raspberry
as a cure for renal diseases in Chinese traditional
medical practice.
Keywords:
Diuretic
activity, Rubus idaeus L., Rasberry, Herbal medicine.
