Tropical Journal of Pharmaceutical Research

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Research Article

Analgesic and Anti-inflammatory Profile of n-Hexane Fraction of Viola betonicifolia

Naveed Muhammad¹, Muhammad Saeed^1*, Syed Naeemuddin Gilani², Ikram ul Haq³ and Haroon Khan¹

¹Department of Pharmacy University of Peshawar, ²Pharmacology Section, PCSIR, Laboratories Complex Peshawar, ³National Institute of Health (NIH), Islamabad, Pakistan

*For correspondence: Email: saeedrph2000@yahoo.com Tel: 009203232175686

Received: 18 October 2011 Revised accepted: 9 November 2012

Tropical Journal of Pharmaceutical Research, December 2012; 11(6): 963-969

http://dx.doi.org/10.4314/tjpr.v11i6.13

Abstract

Purpose: To evaluate the analgesic and anti-inflammatory activities of n-hexane extract of the whole plant of Viola betonicifolia Sm, family: Violaceace.

Methods: The n-hexane fraction of Viola betonicifolia (VBHF) was tested for its analgesic and anti-inflammatory activities (carrageenan-induced and histamine-induced edema models) in BALB/c mice.

Results: VBHF exhibited significant (p < 0.01) analgesic and anti-inflammatory activity at test doses of 100, 200 and 300 mg/kg. The analgesic effect of VBHF was dose-dependent in acetic acid pain model while the extract was a weak analgesic at the dose of 300 mg/kg in hot plate and tail immersion test. Diclofenac sodium and tramadol showed better analgesic properties to the extract. Analgesia was not antagonized by naloxone in the hot plate model. Anti-inflammatory activity against carrageenan-induced edema was 60.8 %; however, histamine-induced inflammation was not antogonised by the extract.

Conclusions: The extract has some analgesic and anti-inflammatory activities. This justifies its use in traditional medicine for pain of management.

Keywords: Viola betonicifolia, Analgesic, Anti-inflammatory.