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Research Article

 

Comparison of Weibull and Probit Analysis in Toxicity Testing of Hunteria umbellata K Schum (Apocynaceae) Extract in Mice

Sunny A Osagie1, Ighodaro Igbe2* and Joseph E Osemwenkhae1

1Department of Mathematics, Faculty of Physical Sciences, 2Department of Pharmacology and Toxicology, Faculty of Pharmacy, University of Benin, Benin City, Nigeria

*For correspondence: Email: igbe.ighodaro@uniben.edu; Tel: +234-8166058559

Received: 7 November 2011                                               Revised accepted: 13 October 2012

Tropical Journal of Pharmaceutical Research, December 2012; 11(6): 933-938

http://dx.doi.org/10.4314/tjpr.v11i6.9  

Abstract

 

Purpose; Hunteria umbellata has been found to have therapeutic potentials in the treatments of diseases such as yaws, peptic ulcers, diabetes, piles and infertility in Nigeria; hence, the statistical analysis on the determination of acute toxicity of Hunteria umbellata was carried out in mice.

Methods; Data on the acute toxicity studies of the seed extract of Hunteria umbellata administered via the intraperitoneal route was analyzed using the two-parameter Weibull model.

Results; The median lethal dose (LD50) was 1.61 g/kg of body weight. This result falls in the neighbourhood of the median lethal dose earlier obtained in previous reports.

Conclusion; The results show that Hunteria umbellata may be slightly toxic when administered intraperitoneally.

 

Keywords: Hunteria umbellata, Weibull model, Acute toxicity, Median lethal dose (LD50).

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