Development of Transdermal
Ondansetron Hydrochloride for the Treatment of
Chemotherapy-Induced Nausea and Vomiting
Rajan Rajabalaya*, Ding
Siok Chen and Sheba Rani Nakka David
Department of Pharmaceutical Technology, International
Medical University, No. 126, Jalan Jalil Perkasa 19,
Bukit Jalil 57000, Kuala Lumpur, Malaysia.
*For correspondence:
Email:
rajan_rajabalaya@imu.edu.my Tel: +60
327317210; Fax: +60 386567229
Received: 6 July 2012
Revised accepted:
17 April 2013
Tropical Journal of
Pharmaceutical Research, June 2013;
12(3): 279-285
http://dx.doi.org/10.4314/tjpr.v12i3.1
Abstract
Purpose: To
to
develop and evaluate matrix-type ondansetron
hydrochloride (OS) transdermal patch for the treatment
of chemotherapy-induced nausea and vomiting.
Methods: Transdermal patches were
prepared by solvent casting method using ethyl cellulose and polyvinyl
pyrrolidone as matrix materials, and dibutyl phthalate
and dibutyl sebacate as plasticizers. The formulations were
evaluated for
patch thickness, tensile strength, moisture content,
water absorption capacity and drug content. In vitro
drug release and permeation of the patches were
determined using a Franz diffusion cell.
Results: the tensile strength of all
the formulations was in the range from 6.09 to 9.85 Mpa
indicating that the [patches were strong. Maximum drug
release in 8 h for dibutyl phthalate DBP and dibutyl
sebacate DBS patches was 38.9 (DB6) and 53.4 % (DS3),
respectively, which are significantly (p < 0.01) higher
than the lowest values of 17.8 (for DB1) and 35.0 % for
(DS5), respectively. Drug release rate was 1.89 and 3.93
μg/h/cm2, respectively with DS2 and DB2
showing the highest permeation rate of 5.39 μg/h/cm2.
Patches containing DBP followed Higuchi release model
while patches formulated with DBS followed first order
release kinetics.
Conclusion: Ondansetron matrix-type
transdermal patches formulated with suitable amounts of
chemical enhancers for better patient compliance are
feasible.
Keywords: Ondansetron hydrochloride,
Chemical enhancers, Plasticizers, Dibutyl phthalate,
Dibutyl sebacate, Permeation, Patch.
