Formulation and Evaluation
of Spray-Dried Esomeprazole Magnesium Microspheres
Achin Jain, MN Ravi Teja,
Laxman Pariyani, V Balamuralidhara and N Vishal Gupta*
Department of Pharmaceutics,
JSS College of Pharmacy, JSS University, Sri
Shivarathreeshwara Nagar, Mysore - 570 015, Karnataka,
India.
*For correspondence:
Email: vkguptajss@gmail.com;
Tel: +91-821-2548353
Received: 4 September 2012
Revised accepted: 19 April 2013
Tropical Journal of
Pharmaceutical Research, June 2013;
12(3): 299-304
http://dx.doi.org/10.4314/tjpr.v12i3.4
Abstract
Purpose: To prepare and evaluate in vitro
mucoadhesive esomeprazole magnesium microspheres for the
treatment of Zollinger Ellison syndrome.
Methods: The microspheres were prepared by
spray drying technique using locust bean and xanthan
gums as polymers. Esomeprazole magnesium was entrapped
in the microspheres at various polymer/cross-linking
ratios. Glutaraldehyde was used to cross-link the gums.
The microspheres were evaluated for their micromeritic
properties and in vitro release. as well as by Fourier
transform infrared (FTIR), differential scanning
calorimetry (DSC) and scanning electron microscopy (SEM).
Results: The microspheres were discrete,
spherical, and showed good drug entrapment efficiency
(60.5 - 92.3 %). FTIR and DSC results indicate that the
drug was compatible with the polymers used. Amongst all
the formulations, F6 (drug:locust bean gum:xanthan gum,
1:2:2) showed the most suitable sustained release
properties with 99.8 % of drug released at the end of 12
h.
Conclusion: Microspheres prepared using locust
bean and xanthan gums can be used as a sustained release
delivery system for esomeprazole magnesium.
Keywords: Spray drying, Microspheres,
Esomeprazole magnesium, Sustained release
