Investigation of
Association between Slime Production by Candida Spp
and Susceptibility to Fluconazole and Voriconazole
Banu Kaskatepe* and
Sulhiye Yildiz
Ankara University, Faculty of
Pharmacy, Department of Pharmaceutical Microbiology,
Ankara, Turkey
*For correspondence:
Email:
bkaskatepe@ankara.edu.tr,
Tel: +90 312 2033188; Fax: + 90 312 213181
Received: 17 November 2012
Revised accepted: 4 June 2013
Tropical Journal of
Pharmaceutical Research, October 2013;
12(5):
821-825
http://dx.doi.org/10.4314/tjpr.v12i5.24
Abstract
Purpose: To determine the
susceptibilities of fluconazole and voriconazole based
on slime production by Candida spp.
Methods: Candida strains (115)
isolated in the period between January 2011 and January
2012 were included in this study. Conventional methods
were used for the identification. Candida albicans and
non-C. albicans isolates were tested for slime
production with modified tube adherence test and
antifungal resistance with disk diffusion method.
Results:
Slime positivity was 31.3 %
in all Candida species. Slime positivity in non-C.albicans
isolates (44.89 %) was higher than in C. albicans
species (21.21 %). All C. albicans isolates were
sensitive to fluconazole and voriconazole. The highest
resistance to fluconazole (40 %) and voriconazole (5%)
was by C. glabrata strains.
Conclusion: Species definition and
determination of antifungal susceptibility patterns are
advised for the proper management and treatment of
patients.
Keywords: Candida, Fluconazole,
Voriconazole, Antifungal susceptibility, Slime
