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Original Research Article
Formulation and In
vitro Evaluation of Ibuprofen-Loaded
Poly(D,L-lactide-co-glycolide) Microparticles
MA Momoh1*, MO
Adedokun2, SB Lawal3 and GO Ubochi1
1Drug Delivery Research Unit,
Department of Pharmaceutics, University of Nigeria,
Nsukka 410001, 2Department of Pharmaceutical
Technology and Pharmaceutical Microbiology, University
of Uyo, Uyo, 3Department of Biochemistry,
Usman Danfodiyo University, Sokoto, Nigeria
*For correspondence:
Email:
jointmomoh@yahoo.com; Tel:
+234-8037784357
Received: 2 February 2013
Revised accepted: 29 August
2014
Tropical
Journal of Pharmaceutical Research, October 2014;
13(10): 1571-1576
http://dx.doi.org/10.4314/tjpr.v13i10.1
Abstract
Purpose: To enhance and control the
release of ibuprofen from poly(D,L-lactide-co-glycolide)
(PLGA) microparticles.
Methods: Ibuprofen-loaded
microparticles containing PLGA were formulated using a
emulsification/solvent evaporation method. Various
concentrations of ibuprofen (200, 300, 400 and 0 mg)
were loaded into the PLGA microparticles and the
formulations labeled A, B, C and D, respectively. The
microcapsules were characterized for drug loading,
particle size, polydispersity index, zeta potential (ZP)
and drug release.
Results: The zeta potential of the
microparticles were -53, -68.7, -43.1, and -37.4 mV for
batches A, B, C and D, respectively. Polydispersity
index ranged from 0.745 to 0.900. Encapsulation
efficiency (EE %) and loading capacity (LC) ranged from
83.4 to 89.3 and 23.4 to 30.1, respectively. Maximum and
minimum release of 92 and 72.0 % at 18 h were obtained
for batches C and A, respectively.
Conclusion: The study shows that PLGA-loaded
with ibuprofen can serve as an alternative carrier for
controlled release of ibuprofen.
Keywords: Ibuprofen, Microparticles,
Controlled release, Zeta potential, Polydispersity |
