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Original Research Article
Anti-Thrombotic Effect of
Carthamus tinctorius Linn Extracts in Rats
Sheng-hao Wu1*,
Cui-ping Zheng1, Song-yan Chen1,
Xiao-ping Cai1, Yue-jian Shi1,
Zhen Liu1 and Zhen-yu Li2
1Department of Hematology, The
Dingli Clinical Institute of Wenzhou Medical University
(Wenzhou Central Hospital), Wenzhou, Zhejiang, 325000,
2Department of Hematology, The Affiliated
Hospital of Xuzhou Medical College, Xuzhou, Jiangsu,
221000, China
*For correspondence:
Email:
546939322@qq.com; Tel: +86
15971479069
Received: 13 August 2013
Revised accepted: 22
September 2014
Tropical
Journal of Pharmaceutical Research, October 2014;
13(10): 1637-1642
http://dx.doi.org/10.4314/tjpr.v13i10.10
Abstract
Purpose: To explore the effects of
Carthamus tinctorius L. (CTL) extracts on thrombosis in
rats.
Methods: CTL extract was obtained in
hot water (60 oC), dried in a hot air oven
and then freeze-dried. The rats were divided into 6
groups: normal group, control group, reference group
(aspirin 5 mg/kg) as well as groups that received 20, 40
and 80 mg/kg doses of CTL, respectively. For each group,
treatment was given orally once daily for 14 days.
Common carotid artery FeCl3-induced thrombus
and inferior vena cava thrombosis occlusion time, as
well as plasma concentrations of thromboxane B2 (TXB2)
and 6-keto-prostaglandine F1α(6-keto-PGF1α) were
measured in rats.
Results: Compared with the control
group, all doses of CTL extracts significantly and
dose-dependently prolonged thrombosis occlusion time,
reduced the weight of thrombus and increased inhibition
rate (p < 0.01). Plasma TXB2 concentration of all CTL
extracts groups decreased dose-dependently (p < 0.05)
while that of 6-keto-PGF1α was increased (p < 0.05).
There was association between 6-keto-PGF1α/TXB2 and
arterial or venous thrombus weight for all treatments,
and also with occlusion time for CTL treatment but not
for aspirin.
Conclusion: CTL has a significant
effect on thrombosis in rats. However, further studies
are required to determine its clinical potentials.
Keywords: Carthamus tinctorius L.,
Thrombosis, Thromboxane B2, 6-Keto-prostaglandin F1α,
Aspirin, Occlusion time |
