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Original Research Article


Prevalence of Hepatitis B and C Virus in Euthyroid Patients

 

X Xu1, KM Sajid2, X Zhai3, W Yao4, S Mir5, R Mahmood4, AK Khan5, MHHB Asad6, K Farzana7, G Murtaza6, T Li3*

1Zhengzhou Traditional Chinese Medicine Hospital, Zhengzhou, China, 2Multan Institute of Nuclear Medicines and Radiology, Nishtar Hospital, Multan, Pakistan, 3Beijing University of Chinese Medicine, Beijing, 4China Development Bank, Beijing, China, 5Department of Chemistry, 6Department of Pharmacy, COMSATS Institute of Information Technology 22060, Abbottabad, 7Department of Pharmaceutical Sciences, Riphah International University, Lahore, Pakistan

 

*For correspondence: Email: gmdogar356@gmail.com; Tel: 0092-3142082826; Fax: 0092-992383441

 

Received: 26 May 2014                                                                          Revised accepted: 13 September 2014 

 

Tropical Journal of Pharmaceutical Research, October 2014; 13(10): 1703-1706

http://dx.doi.org/10.4314/tjpr.v13i10.19   

Abstract

 

Purpose: To determine the prevalence of hepatic infections, viz, hepatitis B (HBV) virus and hepatitis C virus (HCV), in the euthyroid population of Southern Punjab Province of Pakistan.

Methods: A total of 120 euthyroid patients (36 male and 84 female) with a mean age of 30.7 ± 0.09 years) were included in this study. HBV and HCV, as well as the thyroid hormones, namely, triiodothyronine (T3), thyroxine (T4), and thyroid-stimulating hormone (TSH) were detected in the serum of the subjects using commercial kits.

Results: Out of 120 subjects 4 (3.3 %) were positive for HBsAg (hepatitis B surface antigen) and 18 (15 %) for anti-HCV. HCV infection was approximately 4 times higher than HBV infection (p = 0.00028). Prevalence of HBsAg in males (8 %) was significantly higher than in females (1.2 %, p = 0.006345) whereas prevalence of HCV in males (16.7 %) was not significantly different from that in females (14.2 %, p = 0.521303). HCV (16.7 %) was significantly higher than HBV infection (8.33 %, p = 0.0102) in male sufferers. Similarly, among females patients, the incidence of HCV (14.2 %) was significantly higher (p = 0.000011) than HBV infection (1.2 %).

Conclusion: The prevalence of HCV is higher than that of HBV in the studied population; furthermore, this prevalence of HCV is higher than values reported in other studies. The high level of HCV infection in the studied population is of concern, indicating the need for preventive measures to be put in place.

 

Keywords: Hepatitis B, Hepatitis C, Prevalence, Euthyroid

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