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Original Research Article
Protective Effect of
Ethanol Leaf Extract of Carica papaya Linn (Caricaceae)
in Alloxan-induced Diabetic Rats
Abiola F Adenowo1,
Muhibah F Ilori1, Fatai O Balogun2
and Mutiu I Kazeem2*
1Department of Medical
Biochemistry, College of Medicine, University of Lagos,
Lagos, 2Antidiabetic Drug Discovery Group,
Department of Biochemistry, Lagos State University, PMB
0001, Ojo, Lagos, Nigeria
*For correspondence:
Email:
mikazeem@gmail.com
Received: 25 April 2014
Revised accepted: 2 October
2014
Tropical
Journal of Pharmaceutical Research, November 2014;
13(11): 1 877-1882
http://dx.doi.org/10.4314/tjpr.v13i11.15
Abstract
Purpose: To investigate the
ameliorative effect of ethanolic extract of Carica
papaya leaves in alloxan - induced diabetic rats.
Methods: Rats were randomly divided
into five groups of eight animals each. Group A
(control) comprised normal healthy animals which were
orally administered 1.0 ml of distilled water daily for
21 days while groups B – E consisted of alloxan-induced
diabetic rats. Group B comprised diabetic untreated
rats, and groups C and D received 1.0 ml of 250 mg/kg
and 500 mg/kg body weight of the extract, respectively.
Group E received 300 mg/kg of metformin.
Results: Administration of the
extract to the diabetic rats significantly reduced (p <
0.05) glucose level (123.50 mg/dl), total cholesterol (TC),
triglyceride (1.24 mg/dl) and low density lipoprotein
cholesterol (LDL-C), while significantly increasing (p <
0.05) high density lipoprotein cholesterol (HDL-C) and
total protein level (66.51 g/dl) compared to the
diabetic untreated rats. The extract also significantly
decreased (p < 0.05) the concentration of serum urea
(12.35 mg/dl), creatinine, alanine aminotransferase
(ALT) and aspartate aminotransferase (AST) of the
diabetic rats.
Conclusion: The ethanol leaf extract of
Carica papaya ameliorates metabolic disorder caused by
diabetes in rats.
Keywords: Diabetes, Carica papaya,
Glucose, Lipid profile, Alloxan monohydrate |
