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Original Research Article
Sensitivity and
Specificity of Cystatin C in Detecting Early Renal
Impairment in Hypertensive Pregnancies
Fauziah Jummaat1,
Azreen Syazril Adnan2, Nor Aliza Abd Ghaffar1,
Julia Omar3, Syed Hatim Noor4,
Nurul Jannah Ambak4 and Amer Hayat Khan5
1Department of Obstetrics &
Gynecology, 2 CKD Resource Centre, Hospital
Universiti Sains Malaysia, 3Department of
Chemical Pathology, School of Medical Sciences,
Universiti Sains Malaysia, Kubang Kerian, 16150,
Kelantan, Malaysia, 4Unit of Biostatistics
and Research Methodology, School of Medical Sciences,
Universiti Sains Malaysia, Kubang Kerian, 16150,
Kelantan, 5Department of Clinical Pharmacy,
School of Pharmaceutical Sciences, Universiti Sains
Malaysia, 11800 Penang, Malaysia
*For correspondence:
Email:
drfauziahjummaat@gmail.com;
Tel: 0060-12-9480982
Received: 30 January 2012
Revised
accepted: 16 April 2014
Tropical
Journal of Pharmaceutical Research, May 2014;
13(5): 747-751
http://dx.doi.org/10.4314/tjpr.v13i5.14
Abstract
Purpose:
To determine the cutoff
point of cystatin C for the detection of renal
impairment in hypertensive pregnancies.
Methods:
A cross-sectional study was
conducted in an antenatal clinic and ward at Hospital
Universiti Sains Malaysia, Kelantan, Malaysia from
January 2009 until January 2010. Sixty four pregnant
patients beginning at 2nd trimester, aged of 16 to 55
years and hypertensive, including gestational
hypertension, chronic hypertension with superimposed
preeclampsia, preeclampsia and unclassified
hypertension, were included in the study. Consenting
patients were required to provide 5 ml of blood and 24-h
urine. Serum and reagent, N Latex cystatin C, were
equilibrated at room temperature and measured by
particle-enhanced nephelometric immunoassay (PENIA)
using a BN II Dade Behring Nephelometer System
Results:
The mean age of the patients
was 37.06 ±4.32 (range: 24 to 46 years). A majority
(64.1 %) of the patients were in the second trimester of
pregnancy and delivered in the gestational period of 38
- 40 weeks (54.7 %). The number of patients in chronic
kidney disease (CKD) stages I, II, III, IV and V were 25
(39.1 %), 18 (28.1 %), 18 (28.1 %), 2 (3.1 %) and 1 (1.6
%), respectively. The mean systolic blood pressure was
149.59 ± 18.79 mm Hg, and diastolic blood pressure 91.53
± 10.33 mm Hg. The cutoff point in detecting renal
impairment using cystatin C was > 0.74 with 84.6 %
sensitivity and 86.7 % specificity for second trimester
and > 0.81 with sensitivity of 76.9 % and specificity of
60.0 % in detecting renal impairment for third
trimester.
Conclusion:
The cutoff point in
detecting renal impairment for second trimester is
better than for third trimester since it maximizes the
value of sensitivity and specificity.
Keywords:
Cystatin C, Sensitivity,
Specificity, Renal impairment, Hypertension; Pregnancy |
