|
|
Review Article
Biodegradable Poly(D,L-lactic-co-glycolic
acid)-Based Micro/Nanoparticles for Sustained Release of
Protein Drugs - A Review
Rezaul H Ansary, Mohamed B
Awang and Mokhlesur M Rahman*
Kulliyyah of Pharmacy,
International Islamic University Malaysia, 25200 Kuantan,
Malaysia
*For correspondence:
Email:
mdrahman@iium.edu.my
Received: 10 July 2013
Revised accepted: 16 April
2014
Tropical
Journal of Pharmaceutical Research, July 2014;
13(7): 1179-1190
http://dx.doi.org/10.4314/tjpr.v13i7.24
Abstract
Biodegradable poly(D, L-lactide-co-glycolide) (PLGA) and
PLGA-based polymeric nanoparticles are widely used for
sustained release of protein and peptide drugs. These
formulations are usually prepared by water/oil/water
(W/O/W) and solid/oil/water (S/O/W) double emulsion
solvent evaporation method. Other methods of preparation
are nanoprecipitation, emulsion solvent diffusion and
salting-out. This review attempts to address the effects
of PLGA molecular weight, lactide to glycolide ratio,
crystallinity, hydrophilicity as well as nanoparticles
preparation variables (e.g., homogenizer speed,
surfactants nature and concentration) on the size,
morphology, drug encapsulation efficiency and release
profile of PLGA mico/nanoparticles. The current
knowledge of protein instability during preparation,
storage and release from PLGA micro/nanoparticles and
protein stabilization approaches has also been discussed
in this review.
Keywords: Poly(D, L-lactic-co-glycolic acid),
Nanoparticles, Microparticles, Protein/peptides,
Sustained release, Protein instability |
