Tropical Journal of Pharmaceutical Research

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Original Research Article

A Study of the Association of Polymorphism rs5860110 and its Protective Role against Ankylosing Spondylitis in a Chinese Population

Xiufang Wang and Zhaoqing Zhang*

Department of Rehabilitation, The Third Hospital of Wuhan, Wuhan, Hubei Province, 430060, China

*For correspondence: Email: 187076605@qq.com

Received: 8 June 2014 Revised accepted: 18 August 2014

Tropical Journal of Pharmaceutical Research, September 2014; 13(9): 1545-1548

http://dx.doi.org/10.4314/tjpr.v13i9.23

Abstract

Purpose: To investigate whether secreted phosphoprotein-1（SPP1） promoter variants are associated with susceptibility to ankylosing spondylitis (AS) in the western China.

Methods: The rs5860110 variant of SPP1 promoter was genotyped using direct sequencing in 120 unrelated AS patients and 106 ethnically matched healthy controls. All the patients were human leukocyte antigen （HLA）-B27 positive. Frequencies of different genotypes and alleles were analyzed among the AS patients and the controls.

Results: In AS patient group, frequency of +254 SPP1 promoter genotype was 0.483 in base TG/TG homozygotes and 0.517 in TG-(deletion)/TG-(deletion) homozygotes, while the values for the control group were 0.311 and 0.689, respectively. However, TG-(deletion)/TG heterozygote was not detected in this study. The rs5860110 single nucleotide polymorphism (SNP) in SPP1 was significantly different when all AS patients were compared to controls (p < 0.01).

Conclusion: The rs5860110 SNP in SPP1 has a protective role against AS in the selected Chinese population.

Keywords: Polymorphism, Ankylosing spondylitis, Secreted phosphoprotein-1, Sequencing, Genotype, Alleles