Formulation of the extract of the stem bark of
tablet dosage form
SO Majekodunmia, OA Adegokeb and
of Pharmaceutics and Industrial Pharmacy, and bDepartment
of Pharmaceutical Chemistry, Faculty of Pharmacy,
University of Ibadan, Ibadan, Nigeria.
Tel: 2348033235828; 23428106403
Journal of Pharmaceutical Research, June
To formulate the extracts of the stem bark of Alstonia boonei, an
important antimalarial herb, into tablet dosage form.
Tablets were formulated using direct compression and wet
granulation methods. The mechanical properties of the
tablets were assessed using crushing strength and
friability and the crushing strength:friability ratio (CSFR)
while drug release properties were evaluated using
disintegration and dissolution times.
There were statistically significant (p<0.01)
differences in the CSFR values and drug release
properties of A. boonei tablets prepared by both
methods. The differences depended on the type and
concentration of excipient and binder employed in the
The method of preparation of the A. boonei tablets needs to be carefully
selected to ensure the production of tablets with
adequate bond strength to withstand the rigours of
handling and at the same time release the active
compound (s) for biological action.
Alstonia boonei, excipient, binder, tablets, mechanical
properties, drug release properties