Formulation of the extract of the stem bark of Alstonia boonei as tablet dosage form

SO Majekodunmi^a, OA Adegoke^b and OA Odeku^a*

^aDepartment of Pharmaceutics and Industrial Pharmacy, and  ^bDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Ibadan, Ibadan, Nigeria.

Correspondence: E-mail: pejuodeku@yahoo.com   Tel: 2348033235828; 23428106403

Tropical Journal of Pharmaceutical Research, June 2008; 7(2): 987-994

Abstract

Purpose: To formulate the extracts of the stem bark of Alstonia boonei, an important antimalarial herb, into tablet dosage form.

Methods: Tablets were formulated using direct compression and wet granulation methods. The mechanical properties of the tablets were assessed using crushing strength and friability and the crushing strength:friability ratio (CSFR) while drug release properties were evaluated using disintegration and dissolution times.

Results: There were statistically significant (p<0.01) differences in the CSFR values and drug release properties of A. boonei tablets prepared by both methods. The differences depended on the type and concentration of excipient and binder employed in the formulation.

Conclusions: The method of preparation of the A. boonei tablets needs to be carefully selected to ensure the production of tablets with adequate bond strength to withstand the rigours of handling and at the same time release the active compound (s) for biological action.

Keywords:  Alstonia boonei, excipient, binder, tablets, mechanical properties, drug release properties